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A 51-year-old man was brought to the emergency department with severe abdominal pain and hypotension. He had no known chronic medical disease but for the past few months had experienced a loss of appetite, weakness, and fatigue. Despite these symptoms, he had not missed work (electrical engineer). Over the six months, his weight had fallen from 190 to 175 pounds. He did not recall night sweats or fever, but did mention that he experienced a loss of appetite and occasional nausea. On two occasions during the prior week, he vomited.
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Testing patients with abdominal symptoms for celiac disease in primary care settings using IgA tissue transglutaminase antibodies and IgA endomysial antibodies yielded high sensitivity and specificity, justifying their use widely for diagnosis.
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Everolimus, a derivative of sirolimus, is a mammalian target of rapamycin (mTOR) inhibitor.
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Combining extended physical therapy and high-dose cholecalciferol can reduce two different complications of hip fracture: falls and hospital readmission.
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Fibrates can reduce the risk of major cardiovascular events predominantly by prevention of coronary events, and might have a role in treating individuals who are at especially high risk of cardiovascular events and in those with combined dyslipidemia.
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The more bike riding a premenopausal women does, the less likely she is to gain weight.
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Male sexual dysfunction is well recognized as a consequence of diabetes.
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A randomized controlled trial showed that low-dose colchicine, 1.2 mg initially followed by 0.6 mg at 1 hour, was equally effective with fewer side effects as high-dose colchicine, eight 0.6 mg pills over 6 hours. The < 40% response rate with 23% getting diarrhea in the low-dose group calls into question whether colchicine is the superior choice over NSAIDs for acute gout.
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Aggressive approach to CVD reduces MI, folic acid and vitamin B12 for CAD, corticosteroids for acute exacerbations of COPD, prescription drug abuse among young adults, and ARBs and cancer risk.